Is Ovarian Cancer A Single Entity?

فهرست عناوین اصلی در این پاورپوینت

فهرست عناوین اصلی در این پاورپوینت

● A Personalized Approach to Ovarian Cancer:
One Size No Longer Fits All
● Disclosures/Interests
● Disclosures
● One of my First Patients: Erin
● Johns Hopkins Center for Rare Gynecologic Cancers
● Objectives
● Ovarian Cancer
● Epithelial Subtypes
● Is Ovarian Cancer A Single Entity?
● Tumor Grade
● What Are Genetic Mutations?
● Different Types of Genetic Mutations
● Epithelial Ovarian Cancer
● Epithelial Ovarian Cancer Differences
● One Size Doesn’t Fit All
● Precision Medicine
● Precision Medicine Initiative
● Precision Medicine in Cancer
● Cancer Genomics
● Molecular/Genomic Profiling of Tumors
● A Developing Industry
● Profiling Report
● Examples of Precision Medicine
● The Dilemma
● Examples of Precision Medicine in Ovarian Cancer Screening
● The Pap Smear Story
● Pap Smear and DNA Testing
● Pap Smear..the Old Becomes New?
● Advances in Ovarian Cancer Screening
● Circulating Tumor DNA
● Study Methods
● Results
● Ovarian Pap Gene & Circulating Tumor DNA Results
● Precision Medicine in Ovarian Cancer?
● Evolution of Clinical Trials in Rare Ovarian Cancers
● Standard treatment for epithelail ovarian cancer: NCCN
● Clear Cell and Mucinous Tumors
● Rare Epithelial Ovarian Cancer Subtypes
● Two-tiered Histologic Criteria
● Map Kinase Pathway
● Hormonal Receptors
● Mutations of Low-grade Serous
● Epidemiology
● Surgery is the mainstay of therapy!
● Survival by Residual Disease After Primary Cytoreductive Surgery:
GOG 182
● Neoadjuvant chemotherapy?
● Chemotherapy After Primary Cytoreductive Surgery?
● MEK Inhibition: GOG 239
● Chemotherapy for Recurrence: Appraisal
● Ongoing Studies:
NRG/GOG 281
● MILO Study (MEK Inhibitor in Low-grade Serous Ovarian Cancer)
● The Johns Hopkins Experience
● Hormonal Therapy and Low Grade Serous
● Patient Case
● Response to Letrozole
● NCCN Ovarian Cancer Guidelines
● Hypothesis
● Study Schema
● Conclusions
● Thank You!

نوع زبان: انگلیسی حجم: 9.71 مگا بایت
نوع فایل: اسلاید پاورپوینت تعداد اسلایدها: 70 صفحه
سطح مطلب: نامشخص پسوند فایل: ppt
گروه موضوعی: زمان استخراج مطلب: 2019/05/17 04:50:32

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عبارات مهم استفاده شده در این مطلب

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ovarian, cancer, tumor, cell, grade, treatment, mutation, medicine, epithelial, disease, genetic, woman,

توجه: این مطلب در تاریخ 2019/05/17 04:50:32 به صورت خودکار از فضای وب آشکار توسط موتور جستجوی پاورپوینت جمع آوری شده است و در صورت اعلام عدم رضایت تهیه کننده ی آن، طبق قوانین سایت از روی وب گاه حذف خواهد شد. این مطلب از وب سایت زیر استخراج شده است و مسئولیت انتشار آن با منبع اصلی است.

https://ocrahope.org/wp-content/uploads/2018/07/Sun-1100am-Fader-FINAL.ppt

در صورتی که محتوای فایل ارائه شده با عنوان مطلب سازگار نبود یا مطلب مذکور خلاف قوانین کشور بود لطفا در بخش دیدگاه (در پایین صفحه) به ما اطلاع دهید تا بعد از بررسی در کوتاه ترین زمان نسبت به حدف با اصلاح آن اقدام نماییم. جهت جستجوی پاورپوینت های بیشتر بر روی اینجا کلیک کنید.

عبارات پرتکرار و مهم در این اسلاید عبارتند از: ovarian, cancer, tumor, cell, grade, treatment, mutation, medicine, epithelial, disease, genetic, woman,

مشاهده محتوای متنیِ این اسلاید ppt

مشاهده محتوای متنیِ این اسلاید ppt

a personalized approach to ovarian cancer one size no longer fits all amanda nickles fader md associate professor and director the kelly gynecologic oncology service johns hopkins medicine disclosures interests i have no financial relationships to disclose i have a strong clinical and research interest in rare gynecologic cancers and in developing screening tests for ovarian cancer direct the center for rare gynecologic cancers at johns hopkins and co direct the ovarian cancer center of excellence a member of the rare tumor committee nrg gynecologic oncology group disclosures it is only about things that do not interest one that one can give really unbiased opinions which is no doubt the reason why an unbiased opinion is always valueless. oscar wilde one of my first patients erin optimal debulking surgery stage iii low grade serous carcinoma a chemo regimen that included carbo doxil avastin no evidence of disease x ۹ years johns hopkins center for rare gynecologic cancers emphasizes personalized patient cented care for women with low grade serous ovarian carcinoma clear cell and mucinous tumors of the ovary germ cell ie dysgerminoma immature teratoma etc and sex cord stromal tumors of the ovary ie granulosa cell tumors objectives to review the environmental molecular and genetic differences in the epithelial ovarian cancer subtypes to define personalized medicine and how it relates to ovarian cancer care to understand the evidence supporting best treatment strategies for women with rare epithelial ovarian tumors ovarian cancer ovarian cancer diagnosed in approximately ۲۳ women annually in the united states nearly ۹ of ovarian malignancies are epithelial ovarian tumors epithelial subtypes serous carcinomas ۷۵ of all epithelial ovarian cancer high grade ۶۵ and low grade serous ۱ clear cell ۱۱ endometrioid ۱۱ mucinous ۳ malpica et al am j pathol ۲ ۷ vang et al am j surg path ۲ ۸ although several studies have shown that histologic grade is an important prognostic factor in serous carcinoma of the ovary no universal grading system has been accepted is ovarian cancer a single entity historically women w epithelial ovarian cancer treated similarly and lumped in the same surgery and chemo treatment trials irrespective of their tumor subtype differences in genetic profiles tumor biology and treatment responses among women with different tumor types were discovered with a distinction emerging between tumor types to lump or split tumor grade the description of a tumor based on how abnormal the tumor cells and the tumor tissue look under a microscope an indicator of how quickly a tumor is likely to grow and spread low grade or high grade low grade high grade what are genetic mutations dna our genetic makeup made up of chromosomes which include many genes gene mutation a permanent change in dna sequence that makes up a gene such that the sequence differs from what is found in most people mutations range in size can affect anywhere from a single dna building block to a large segment of a chromosome with multiple genes different types of genetic mutations hereditary mutations inherited from a parent are present throughout a person’s life in every cell in the body are germline mutations are present in the parent’s egg or sperm cells also called germ cells acquired somatic mutations occur at some time during a person’s life are present only in certain cells caused by environmental factors or can occur if a mistake is made as dna copies itself during cell division acquired mutations in somatic cells cells other than sperm and egg cells cannot be passed on to the next generation epithelial ovarian cancer epithelial ovarian cancer eoc is not one but several distinct entities more than one disease advances in the understanding of ovarian malignancies refining pathologic diagnostic criteria molecular biology and genetics jemal cancer stats. ۲ ۱۴ over the past decade it has become increasingly clear that ovarian cancer is not one but several distinct entities. even today the vast majority of ovarian cancer clinical trials include women with all histologic subtypes. such is true in trials for both front line and recurrent treatment. however advances in our understanding of the heterogeneity of ovarian cancer have emerged on the basis of refinement of pathologic diagnostic criteria molecular biology and genetic investigations epithelial ovarian cancer differences type i lower grade slower tumor growth genetic mutations—pten kras braf src etc younger women sometimes earlier stage type ii higher grade faster tumor growth genetic mutations in p۵۳ middle age or older women more advanced stage t one size doesn’t fit all most medical treatments are designed for the average patient as a one size fits all approach that is successful for some patients but not for others precision medicine an innovative approach to disease prevention and treatment that takes into account differences in people’s genes environments and lifestyles president obama’s precision medicine initiative precision medicine tailoring of medical treatment to the individual characteristics of each patient the ability to classify individuals into subpopulations that differ in their susceptibility to a particular disease in the biology and or prognosis of those diseases they may develop or in response to a specific treatment preventive interventions or therapies can then be concentrated on those who will benefit sparing expense and side effects for those who will not precision medicine an emerging approach for disease treatment and prevention that takes into account individual variability in genes environment and lifestyle for each person while some advances in precision medicine have been made the practice is not currently in use for most diseases we must gain better insights into the biological environmental and behavioral influences on these diseases to make a difference for the millions of americans who ar e diagnosed with chronic illness far too many diseases do not have a proven means of prevention or effective treatments. precision medicine initiative on january ۲ ۲ ۱۵ president obama announced the precision medicine initiative® the president called for ۲۱۵ million in ۲ ۱۶ to support the initiative which includes several components with efforts from across …

کلمات کلیدی پرکاربرد در این اسلاید پاورپوینت: ovarian, cancer, tumor, cell, grade, treatment, mutation, medicine, epithelial, disease, genetic, woman,

این فایل پاورپوینت شامل 70 اسلاید و به زبان انگلیسی و حجم آن 9.71 مگا بایت است. نوع قالب فایل ppt بوده که با این لینک قابل دانلود است. این مطلب برگرفته از سایت زیر است و مسئولیت انتشار آن با منبع اصلی می باشد که در تاریخ 2019/05/17 04:50:32 استخراج شده است.

https://ocrahope.org/wp-content/uploads/2018/07/Sun-1100am-Fader-FINAL.ppt

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