اسلاید پاورپوینت: امتحان کردن (test) ، گردنی (cervical) و چنگار (cancer)…

 

عناوین اصلی استخراج شده از این فایل پاورپوینت

عناوین اصلی استخراج شده از این فایل پاورپوینت

● Progression from Infection to Cervical Cancer
● CxCa Prevention (primary screening)
● Primary Screening: HPV Detection vs Cytology
● Targets for HPV Detection
● Parameters for Choice
● Commercial PCR-based HPV tests
● Onclarity (BD): Extended Genotyping
● Extended genotyping: OnclARITY (BD) tEST
● Cepheid: Xpert HPV – Test characteristics
● Result – Xpert HPV (Cepheid)
● Result presentation – Xpert HPV
● Advantage by full genotyping
● Full Genotyping: HPV Multiplexed Genotyping
(WHO Reference test)
● Simplicity of Oncoprotein E6 Cervical Test (Workstation Setup)
● Screening results and disease burden
● Biomarker for high-grade and progressive dysplasia
● Summary

نوع زبان : انگلیسی حجم : ۵٫۰۶ مگا بایت
نوع فایل : اسلاید پاورپوینت تعداد اسلایدها: ۳۸ صفحه
زمان استخراج مطلب : ۲۰۱۸/۱۱/۰۲ ۰۵:۲۰:۱۷ پسوند فایل : pptx

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این مطلب در تاریخ ۲۰۱۸/۱۱/۰۲ ۰۵:۲۰:۱۷ به صورت خودکار استخراج شده است. در صورت اعلام عدم رضایت تهیه کننده ی آن، طبق قوانین سایت از روی وب گاه حذف خواهد شد. همچنین این مطلب برگرفته از وب سایت زیر است و مسئولیت انتشار آن با منبع اصلی است.

https://www.vpc.lt/uploads/3_Kaufmann_HPV_Tests_2017_04_26.pptx

بخشی از محتوای متن استخراج شده از این فایل ppt

بخشی از محتوای متن استخراج شده از این فایل ppt

andreas m. kaufmann phd andreas.kaufmann@charite.de clinic for gynecology charité universitätsmedizin berlin germany screening methods for hpv and dysplasia detection prevention of cervical cancer the role of hpv infection vilnius ۲۶.۴.۲ ۱۷ ۱ the most important measure to prevent cervical cancer in future is hpv vaccination cervical cancer – prevention in germany trends in incidence and mortality most effective cancer prevention programme where screening established ۳ amk progression from infection to cervical cancer ۷ ۳ years infection cin ۱ cin ۲ ۳ invasive cxca ca. ۵ ۸ ۱۸ months infection virus production transformation cxca invasion dna detection e۶ e۷ rna protein detection cytology screening methods ۴ aus nature reviews cancer vol. ۷ ۱۱ ۲۲ januar ۲ ۷ basal cells in the cervical epithelium rest on the basement membrane which is supported by the dermis. human papillomavirus hpv is thought to access the basal cells through micro abrasions in the cervical epithelium. following infection the early hpv genes e۱ e۲ e۴ e۵ e۶ and e۷ are expressed and the viral dna replicates from episomal dna purple nuclei . in the upper layers of epithelium the midzone and superficial zone the viral genome is replicated further and the late genes l۱ and l۲ and e۴ are expressed. l۱ and l۲ encapsidate the viral genomes to form progeny virions in the nucleus. the shed virus can then initiate a new infection. low grade intraepithelial lesions support productive viral replication. an unknown number of high risk hpv infections progress to high grade cervical intraepithelial neoplasia hgcin . the progression of untreated lesions to microinvasive and invasive cancer is associated with the integration of the hpv genome into the host chromosomes red nuclei with associated loss or disruption of e۲ and subsequent upregulation of e۶ and e۷ oncogene expression. lcr long control region. abnormal cells in micropscope cxca prevention primary screening when positive triage diagnosis therapy ۱ pap smear ۲ hpv test high risk hpv۱۶ ۱۸ ۳۱ ۳۳ … low risk hpv۶ ۱۱ ۴۲ ….. ۵ ۵ cervical samples liquid based cytology pictured here is the cervical sample collection system using liquid based cytology lbc . a brush like instrument is used to collect cell samples from just inside the cervix which are then placed in liquid and sent to a central laboratory for analysis. the histopathologist examines the stained cells to see if any abnormal cells are present. if there are abnormal cells present the investigator will ask that the subject return to the clinic for a visual examination of the cervix using a colposcope. this is the normal sequence of events in a cervical cancer screening programme. primary screening hpv detection vs cytology cuzick et al. int j cancer ۲ ۸ hpv test high sensitivity but cytology low sensitivity high specificity internationally shift from cytology to hpv test ۲ who „countries that do not yet have cytology established should start directly with hpv testing ۳ maybe use cytology as triage method ۴ potentially better molecular triage tests possible amk parameter of test quality cytology hpv dna sensitivity cin۲ ۵ ۸ ۹۵ specificity ۹۸ ۸ ۹ positive predictive value ۲ ۴ ۱ negative predictive value ۵ ۹۸ post test probability ۱ depending on frame work conditions age interval test characteristics… which conditions adequate for the program amk cuzick et al. bjc ۱ ۸ ۲ ۱۳ @ comparison of ۶ hpv tests in a screening population six hpv tests from residual liquid based screening cytology specimens all tests except for norchip showed high sensitivity for high grade lesions that were positive by cytology suggesting that they are suitable for primary screening and that dual co testing with cytology as well is unnecessary. positivity rates in cytology negative specimens were similar for the dna based tests but were lower for the aptima test suggesting it can maintain the high sensitivity of the dna tests but with a better specificity so that fewer women would need triage tests or short term follow up. however a long term low risk period after a negative test has yet to be demonstrated for aptima or any rna based test as has been shown for some of the dna based tests especially hybrid capture ۲ dillner et al ۲ ۸ cuzick et al ۲ ۸b mesher et al ۲ ۱ rijkaart et al ۲ ۱۲ . direct demonstration of this is desirable to support its use in primary screening the norchip test had lower sensitivity but higher specificity suggesting its role may be more in triage than primary screening. ۸ amk ۱۷۶ ۴۶۴ women aged ۲ –۶۴ years were randomly assigned to hpv based experimental arm or cytology based control arm screening in sweden swedescreen the netherlands pobascam england artistic and italy ntcc . followed up for a median of ۶.۵ years ۱ ۲۱۴ ۴۱۵ person years and identified ۱ ۷ invasive cervical carcinomas invasive cxca after initial screening in rcts in ۲nd round hpv hpv cytology cytology ۶ ۷ ۴۵ higher sensitivity for cin۳ and therapy less cxca incidence in follow up ronco et al. lancet ۲ ۱۴ ۳۸۳ ۵۲۴–۳۲ missed cin۳ cxca in ۱st round new cxca in ۲nd round the rate ratio for invasive cervical carcinoma among all women from recruitment to end of follow up was ・۶ ۹۵ ci ・۴ – ・۸۹ with no heterogeneity between studies p ・۵۲ . detection of invasive cervical carcinoma was similar between screening methods during the first ۲・۵ years of follow up ・۷۹ ・۴۶–۱・۳۶ but was significantly lower in the experimental arm thereafter ・۴۵ ・۲۵– ・۸۱ . in women with a negative screening test at entry the rate ratio was ・۳ ・۱۵– ・۶ . the cumulative incidence of invasive cervical carcinoma in women with negative entry tests was ۴・۶ per ۱ ⁵ ۱・۱–۱۲・۱ and ۸・۷ per ۱ ⁵ ۳・۳–۱۸・۶ at ۳・۵ and ۵・۵ years respectively in the experimental arm and ۱۵・۴ per ۱ ⁵ ۷・۹–۲۷・ and ۳۶・ per ۱ ⁵ ۲۳・۲–۵۳・۵ respectively in the control arm. rate ratios did not differ by cancer stage but were lower for adenocarcinoma ・۳۱ ・۱۴– ・۶۹ than for squamous cell carcinoma ・۷۸ ・۴۹–۱・۲۵ . the rate ratio was lowest in women aged ۳ –۳۴ years ・۳۶ ・۱۴– ・۹۴ . interpretation hpv based screening provides ۶ –۷ greater protection against invasive cervical carcinomas compared with cytology. data of large scale randomised trials support initiation of hpv based screening from age …

کلمات کلیدی پرکاربرد در این اسلاید پاورپوینت: امتحان کردن (test), گردنی (cervical), چنگار (cancer), فرومایه (base), سلول (cell),

این فایل پاورپوینت شامل ۳۸  اسلاید و به زبان انگلیسی و حجم آن ۵٫۰۶ مگا بایت است. نوع قالب فایل pptx بوده که با این لینک قابل دانلود است. این مطلب برگرفته از سایت زیر است و مسئولیت انتشار آن با منبع اصلی می باشد که در تاریخ ۲۰۱۸/۱۱/۰۲ ۰۵:۲۰:۱۷ استخراج شده است.

https://www.vpc.lt/uploads/3_Kaufmann_HPV_Tests_2017_04_26.pptx

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